Nerdy college student Columbus (Jesse Eisenberg) has survived the plague that has turned mankind into flesh-devouring zombies despite being scared of just about everything. Gun-toting, Twinkie-loving Tallahassee (Woody Harrelson) has no fears. As they join forces with Wichita (Emma Stone) and Little Rock (Abigail Breslin) who have also found unique ways to survive the zombie mayhem, they will have to determine which is worse: relying on each other or succumbing to the zombies.