When Michael Scofield's brother, Lincoln, is wrongfully sentenced to death, Michael engineers an impossible escape - from the inside out. But breaking out is just the beginning.

After a deadly cross-country manhunt leads to a nightmarish Panamanian hellhole, Michael, together with the woman he loves and a band of hardened renegades, must bring down a sinister government organisation and somehow manage to stay alive until the day when he can stop running... forever.