Seven years after capturing the heart of his co-anchor and wife, Veronica Corningstone (Christina Applegate), Burgundy (Will Ferrell) is offered the chance of lifetime: to be in on the world's first 24-hour global cable news network, GNN, in New York City.

The newsman quickly rounds up his classic news team - sports guy Champ Kind (David Koechner), man on the street Brian Fantana (Paul Rudd) and weatherman Brick Tamland (Steve Carell) - and heads to The Big Apple. Upon arriving, he is quickly challenged by his strong female boss, Linda Jackson (Meagan Good), Australian multi-millionaire network owner Kench Allenby (Josh Lawson) and a chiseled popular lead anchor, Jack Lime (James Marsden). It's up to Ron and the team to find their own way to the top of news - and the top of the ratings.